A 67-year-old man was found to have a plasma calcium level of 12.2 mg/dL during a follow-up visit. The man had a 3-year history of Hodgkin lymphoma. He was recently diagnosed with nephrolithiasis for which he had been treated with hydrochlorothiazide forthe past 3 weeks. Which of the following best explains the most likely mechanism of thiazideinduced hypercalcemia?
a. Activation of the Na+/Ca2+ exchanger in the distal tubule
b. Increased Ca2+ reabsorption in the proximal tubule
c. Decreased secretion of parathyroid hormone
d. Decreased renal excretion of vitamin D
e. Activation of Na+/K+/2Cl− symporter in the thick ascending loop of Henle
f. Increased glomerular filtration of Ca2+
